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Kinetics of Tumor Spheroid Growth and Survival

To determine kinetics of compound efficacy on 3D tumor spheroids based on live-cell imaging.

​Features of the assay
  • Spheroid growth and viability are measured multiple times over time of treatment.
  • Available for high-throughput screenings.​
  • ​Distinction between cytostatic and cytotoxic effects.

Detailed description
In standard 2D monolayer critical factors of tumors, such as cell-cell and cell-matrix interactions, do not form. In contrast, 3D culture systems offer the advantage of a more tissue-like complexity and heterogeneity, cellular polarity and interactions. Volume and dead cells inside the spheroids, highlighted in green in the image on the right, are monitored over time through live-imaging.


Read Our Method on Pubmed - Contract Research Services
Obinu and colleagues, supported by Kitos Biotech as contract service, evaluated the anticancer activity of their Poly (ethyl 2-cyanoacrylate) nanoparticles on our 3D tumor spheroids models of hepatocellular carcinoma and kidney adenocarcinoma cells. Their work was published on Colloids and Surfaces B: Biointerfaces.

​Link:

Obinu et al. Poly (ethyl 2-cyanoacrylate) nanoparticles (PECA-NP) as possible agents in tumor treatment. Colloids and Surfaces B: Biointerfaces (2019) 177: 520-528. Pubmed ID: 30822627
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ABOUT US
Kitos Biotech is a CRO that supports academics and companies in drug discovery of anticancer products.
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Member of FEDERCHIMICA - ASSOBIOTEC
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Italian Innovative Start-Up
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Supporting Member of Italian Cell Culture Association
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  • About Us
  • Su di Noi
  • Contract Research
  • Ricerca a Contratto
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  • In vitro models
  • Modelli in vitro
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