Nanoparticle Drug Delivery Assay in Tumor Spheroids

To determine efficacy of nanoparticle-based drug delivery systems in tumor spheroids.
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Features of the assay
  • Efficacy of drug delivery is be measured multiple times over a short (time-lapse) or a long period of time by live-cell imaging.​
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Tumor spheroids of various cancer type origin available at Kitos Biotech
Detailed description
Nanoparticulate pharmaceutical drug delivery systems are widely used in pharmaceutical research and in clinical settings to enhance the effectiveness of diagnostic agents and drugs, including anticancer, antimicrobial and antiviral drugs [1]. We established a cell-based assay to evaluate kinetics of efficacy of nanoparticle-based delivery systems in human tumor spheroids taking advantage of live-cell imaging and time-lapse technology.
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References
[1] Torchilin VP. Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery. Nature Reviews Drug Discovery volume 13, pages 813–827 (2014). PMID: 25287120

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Kitos Biotech is a CRO that supports academics and companies in drug discovery of anticancer products.
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