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2/26/2017

A guide to cell-based assays in drug discovery

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Picture©2016 Macmillan Publishers Limited, part of Springer Nature.
In a recent perspective article published on Nature Reviews Drug Discovery (link), various members of the European Cell-Based Assays Interest Group summarized limitations of traditional cell-based disease models and discuss how patient-derived cultures, induced pluripotent stem cell (iPSC) technology and 3D co-cultures, complemented by single-cell imaging, microfluidics and gene editing technologies, could improve clinical significance of  preclinical drug testing. In this view, limitations of standard cell-line screens and in vivo xenografts contributed to the failure of many drug candidates that did not show clinical efficacy:
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11/4/2016

Kitos is on pubmed

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We are proud to announce that a member of our team recently coauthored a paper published in the prestigious Journal of Medicinal Chemistry which shows the activity of novel unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles on the growth of a panel of tumor  and non-tumor cell lines.

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10/30/2016

A cell culture model for Alzheimer's disease

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Researchers from Harvard Medical School, USA, reported in "Nature Protocols" the characterization of a 3D culture system that exhibits key events in Alzheimer's disease pathogenesis, including extracellular aggregation of β-amyloid and accumulation of hyperphosphorylated tau.

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10/26/2016

A new DNA stain for long-term live-cell microscopy

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In order to track individual cells in live-cell imaging, fluorescent DNA stains can be used as intracellular reference markers. Hoechst 33342 would be the best option to monitor cell proliferation in live-cell imaging since it is highly selective for DNA, fluorogenic in wash-free imaging and applicable in different cell types. However, Hoechst 33342 shows toxicity to live cells in long-term exposure because of the phototoxic effect of blue light required for its excitation.

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10/23/2016

Long-term expansion of human cells from liver and pancreas

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Researchers of the University of Cambridge (UK) described, in the prestigious journal "Nature protocols", a method to grow human adult liver and pancreatic cells into self-assembling 3D structures that can sustain long-term expansion. 

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ABOUT US
Kitos Biotech is a CRO that supports academics and companies in drug discovery of anticancer products.
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Member of FEDERCHIMICA - ASSOBIOTEC
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Italian Innovative Start-Up
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Supporting Member of Italian Cell Culture Association
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